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arXiv · 1504.02139

Universal Protein Distributions in a Model of Cell Growth and Division

Naama Brenner·C. M. Newman·Dino Osmanovic·Yitzhak Rabin·Hanna Salman·D. L. Stein
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Abstract

Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal measurements of protein content, showing accumulation and division across generations. Here we present a stochastic growth-and-division model with feedback which captures these observed properties. The limiting copy number distribution is calculated exactly, and a single parameter is found to determine the distribution shape and the variance-to-mean relation. Estimating this parameter from bacterial temporal data reproduces the measured distribution shape with high accuracy, and leads to predictions for future experiments.

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Naama Brenner, C. M. Newman, Dino Osmanovic, Yitzhak Rabin, Hanna Salman, D. L. Stein. 2015-10-22. Universal Protein Distributions in a Model of Cell Growth and Division. https://doi.org/10.1103/physreve.92.042713

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