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arXiv · 1505.02488

Optimal two-treatment crossover designs for binary response models

S. Mukhopadhyay·S. P. Singh·A. Dey
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Abstract

Optimal two-treatment, $p$ period crossover designs for binary responses are determined. The optimal designs are obtained by minimizing the variance of the treatment contrast estimator over all possible allocations of $n$ subjects to $2^p$ possible treatment sequences. An appropriate logistic regression model is postulated and the within subject covariances are modeled through a working correlation matrix. The marginal mean of the binary responses are fitted using generalized estimating equations. The efficiencies of some crossover designs for $p=2,3,4$ periods are calculated. The effect of misspecified working correlation matrix on design efficiency is also studied.

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S. Mukhopadhyay, S. P. Singh, A. Dey. 2015-05-11. Optimal two-treatment crossover designs for binary response models. https://arxiv.org/abs/1505.02488

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