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arXiv · 1508.07787

Detection of basepair mismatches in DNA using graphene based nanopore device

Sourav Kundu·S. N. Karmakar
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Abstract

We present an unique way to detect basepair mismatches in DNA leading to different epigenetic disorder by the method of nanopore sequencing. Based on a tight-binding formulation of graphene nanopore based device, using Greens function approach we measure the changes in the electronic transport properties of the device as we translocate a double-stranded DNA through the nanopore embeded in a zigzag graphene nanoribbon. In the present work we not only successfully detect the usual AT and GC pairs, but also a set of possible mismatches in the complementary base-pairing without any ambiguity. Our investigation shows that this device can also be used for reliable sequential detection of other biomolecules.

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Sourav Kundu, S. N. Karmakar. 2016-02-01. Detection of basepair mismatches in DNA using graphene based nanopore device. https://doi.org/10.1088/0957-4484%2F27%2F13%2F135101

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