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arXiv · 1510.05474

Brownian dynamics simulations of an idealized chemical reaction network under spatial confinement and crowding conditions

Giovanni Bellesia·Benjamin B. Bales
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Abstract

We investigate, via Brownian dynamics simulations, the reaction dynamics of a simple, non-linear chemical network (the Willamowski-Rossler network) under spatial confinement and crowding conditions. Our results show that the presence of inert crowders has a non-nontrivial effect on the dynamics of the network and, consequently, that effective modeling efforts aiming at a general understanding of the behavior of biochemical networks in vivo should be stochastic in nature and based on an explicit representation of both spatial confinement and macromolecular crowding.

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Giovanni Bellesia, Benjamin B. Bales. 2015-11-12. Brownian dynamics simulations of an idealized chemical reaction network under spatial confinement and crowding conditions. https://doi.org/10.1103/physreve.94.042306

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