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arXiv · 1604.01626

Room temperature chiral discrimination in paramagnetic NMR spectroscopy

Alessandro Soncini·Simone Calvello
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Abstract

A recently proposed theory of chiral discrimination in NMR spectroscopy based on the detection of a molecular electric polarization $\mathbf{P}$ rotating in a plane perpendicular to the NMR magnetic field [A. D. Buckingham, J. Chem. Phys. $\mathbf{140}$, 011103 (2014)], is here generalized to paramagnetic systems. Our theory predicts new contributions to $\mathbf{P}$, varying as the square of the inverse temperature. Ab initio calculations for ten Dy$^{3+}$ complexes, at 293K, show that in strongly anisotropic paramagnetic molecules $\mathbf{P}$ can be more than 1000 times larger than in diamagnetic molecules, making paramagnetic NMR chiral discrimination amenable to room temperature detection.

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Alessandro Soncini, Simone Calvello. 2016-04-06. Room temperature chiral discrimination in paramagnetic NMR spectroscopy. https://doi.org/10.1103/physrevlett.116.163001

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