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arXiv · 1604.07489

Ab initio Investigation of Adsorption Characteristics of Bisphosphonates on Hydroxyapatite (001) Surface

Mun-Hyok Ri·Yong-Man Jang·Chol-Jun Yu·Song-Un Kim
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Abstract

The structures of some bisphosphonates (clodronate, etidronate, pamidronate, alendronate, risedronate, zoledronate, minodronate) were obtained and analyzed, and their adsorption energies onto hydroxyapatite (001) surface were compared to find out ranking order of binding affinity, which shows that the adsorption energy is the largest for pamidronate, followed by alendronate, zoledronate, clodronate, ibandronate, the lowest for minodronate and etidronate.

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Mun-Hyok Ri, Yong-Man Jang, Chol-Jun Yu, Song-Un Kim. 2016-04-26. Ab initio Investigation of Adsorption Characteristics of Bisphosphonates on Hydroxyapatite (001) Surface. https://arxiv.org/abs/1604.07489

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