How did prebiotic polymers become informational foldamers?

Elizaveta A Guseva; Ronald N Zuckermann; Ken A Dill

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arXiv · 1604.08890

How did prebiotic polymers become informational foldamers?

Elizaveta A Guseva·Ronald N Zuckermann·Ken A Dill

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Abstract

A mystery about the origins of life is which molecular structures $-$ and what spontaneous processes $-$ drove the autocatalytic transition from simple chemistry to biology? Using the HP lattice model of polymer sequence spaces leads to the prediction that random sequences of hydrophobic ($H$) and polar ($P$) monomers can collapse into relatively compact structures, exposing hydrophobic surfaces, acting as primitive versions of today's protein catalysts, elongating other such HP polymers, as ribosomes would now do. Such foldamer-catalysts form an autocatalytic set, growing short chains into longer chains that have particular sequences. The system has capacity for the multimodality: ability to settle at multiple distinct quasi-stable states characterized by different groups of dominating polymers. This is a testable mechanism that we believe is relevant to the early origins of life.

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Elizaveta A Guseva, Ronald N Zuckermann, Ken A Dill. 2016-04-28. How did prebiotic polymers become informational foldamers?. https://arxiv.org/abs/1604.08890

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