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arXiv · 1606.07807

H(O)TA: estimation of DNA methylation and hydroxylation levels and efficiencies from time course data

Charalampos Kyriakopoulos·Pascal Giehr·Verena Wolf
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Abstract

Methylation and hydroxylation of cytosines to form 5-methylcytosine (5mC) and 5-droxymethylcytosine (5hmC) belong to the most important epigenetic modifications and their vital role in the regulation of gene expression has been widely recognized. Recent experimental techniques allow to infer methylation and hydroxylation levels at CpG dinucleotides but require a sophisticated statistical analysis to achieve accurate estimates.

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Charalampos Kyriakopoulos, Pascal Giehr, Verena Wolf. 2016-06-26. H(O)TA: estimation of DNA methylation and hydroxylation levels and efficiencies from time course data. https://arxiv.org/abs/1606.07807

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