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arXiv · 1608.03695

Cluster of red blood cells in microcapillary flow: hydrodynamic versus macromolecule induced interaction

Viviana Clavería·Othmane Aouane·Marine Thiébaud·Manouk Abkarian·Gwennou Coupier·Chaouqi Misbah·Thomas John·Christian Wagner
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Abstract

We present experiments on RBCs that flow through microcapillaries under physiological conditions. We show that the RBC clusters form as a subtle imbrication between hydrodynamics interaction and adhesion forces because of plasma proteins. Clusters form along the capillaries and macromolecule-induced adhesion contribute to their stability. However, at high yet physiological flow velocities, shear stresses overcome part of the adhesion forces, and cluster stabilization due to hydrodynamics becomes stronger. For the case of pure hydrodynamic interaction, cell-to-cell distances have a pronounced bimodal distribution. Our 2D-numerical simulations on vesicles captures the transition between adhesive and non-adhesive clusters at different flow velocities.

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Viviana Clavería, Othmane Aouane, Marine Thiébaud, Manouk Abkarian, Gwennou Coupier, Chaouqi Misbah, Thomas John, Christian Wagner. 2016-08-12. Cluster of red blood cells in microcapillary flow: hydrodynamic versus macromolecule induced interaction. https://doi.org/10.1039/c6sm01165a

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