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arXiv · 1609.05462

Calcite single crystals as hosts for atomic-scale entrapment and slow release of drugs

Giulia Magnabosco·Matteo Di Giosia·Iryna Polishchuk·Eva Weber·Simona Fermani·Andrea Bottoni·Francesco Zerbetto·Boaz Pokroy·Stefania Rapino·Giuseppe Falini·Matteo Calvaresi
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Abstract

This study presents a complete structural and biological characterization of Doxorubicin CaCO3 single crystals as a pH responsive drug carrier. Using a biomimetic approach, it was demonstrated that calcite single crystals are able, during their growth in presence of doxorubicin, to entrap drug molecules inside their lattice, along specific crystallographic directions. High resolution synchrotron powder diffraction measurements allowed the determination of the lattice distortion and microstructural parameters. Confocal microscopy confirmed that doxorubicin is uniformly embedded in the crystal and that the drug is not only adsorbed on the crystal surface. A slow release of DOX is obtained that occurs preferentially in proximity of the crystals, targeting cancer cells.

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Giulia Magnabosco, Matteo Di Giosia, Iryna Polishchuk, Eva Weber, Simona Fermani, Andrea Bottoni, Francesco Zerbetto, Boaz Pokroy, Stefania Rapino, Giuseppe Falini, Matteo Calvaresi. 2016-09-18. Calcite single crystals as hosts for atomic-scale entrapment and slow release of drugs. https://arxiv.org/abs/1609.05462

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