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arXiv · 1610.01193

Interplay between velocity and travel distance of kinesin-based transport in the presence of tau

Jing Xu·Stephen J. King·Maryse Lapierre-Landry·Brian Nemec
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Abstract

Although the disease-relevant microtubule-associated protein tau is known to severely inhibit kinesin-based transport in vitro, the potential mechanisms for reversing this detrimental effect to maintain healthy transport in cells remain unknown. Here we report the unambiguous upregulation of multiple-kinesin travel distance despite the presence of tau, via decreased single-kinesin velocity. Interestingly, the presence of tau also modestly reduced cargo velocity in multiple-kinesin transport, and our stochastic simulations indicate that the tau-mediated reduction in single-kinesin travel underlies this observation. Taken together, our observations highlight a nontrivial interplay between velocity and travel distance for kinesin transport, and suggest that single-kinesin velocity is a promising experimental handle for tuning the effect of tau on multiple-kinesin travel distance.

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Jing Xu, Stephen J. King, Maryse Lapierre-Landry, Brian Nemec. 2016-10-04. Interplay between velocity and travel distance of kinesin-based transport in the presence of tau. https://doi.org/10.1016/j.bpj.2013.10.006

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