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arXiv · 1610.09536

Stochastic single-molecule dynamics of synaptic membrane protein domains

Osman Kahraman·Yiwei Li·Christoph A. Haselwandter
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Abstract

Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes. We find that the stochastic reaction-diffusion dynamics of synaptic proteins provide a simple physical mechanism for collective fluctuations in synaptic domains, the molecular turnover observed at synaptic domains, key features of the single-molecule trajectories observed for synaptic proteins, and spatially inhomogeneous protein lifetimes at the cell membrane. Our results suggest that central aspects of the single-molecule and collective dynamics observed for membrane protein domains can be understood in terms of stochastic reaction-diffusion processes at the cell membrane.

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Osman Kahraman, Yiwei Li, Christoph A. Haselwandter. 2016-10-29. Stochastic single-molecule dynamics of synaptic membrane protein domains. https://doi.org/10.1209/0295-5075/115/68006

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