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arXiv · 1701.05770

Origin of spatial organization of DNA-polymer in bacterial chromosomes

Tejal Agarwal·G. P. Manjunath·Farhat Habib·Apratim Chatterji
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Abstract

In-vivo DNA organization at large length scales ($\sim 100nm$) is highly debated and polymer models have proved useful to understand the principle of DNA-organization. Here, we show that $<2$% cross-links at specific points in a ring polymer can lead to a distinct spatial organization of the polymer. The specific pairs of cross-linked monomers were extracted from contact maps of bacterial DNA. We are able to predict the structure of 2 DNAs using Monte Carlo simulations of the bead-spring polymer with cross-links at these special positions. Simulations with cross-links at random positions along the chain show that the organization of the polymer is different in nature from the previous case.

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Tejal Agarwal, G. P. Manjunath, Farhat Habib, Apratim Chatterji. 2017-01-20. Origin of spatial organization of DNA-polymer in bacterial chromosomes. https://doi.org/10.1209/0295-5075/121/18004

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