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arXiv · 1701.07940

Inferring clonal composition from multiple tumor biopsies

Matteo Manica·Hyunjae Ryan Kim·Roland Mathis·Philippe Chouvarine·Dorothea Rutishauser·Laura De Vargas Roditi·Bence Szalai·Ulrich Wagner·Kathrin Oehl·Karim Saba·Arati Pati·Julio Saez-Rodriguez·Angshumoy Roy·Donald W. Parsons·Peter J. Wild·María Rodríguez Martínez·Pavel Sumazin
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Abstract

Explicit accounting for copy number alterations can dramatically improve mutation frequency estimates, leading to more accurate phylogeny reconstructions and subclone characterizations.

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Matteo Manica, Hyunjae Ryan Kim, Roland Mathis, Philippe Chouvarine, Dorothea Rutishauser, Laura De Vargas Roditi, Bence Szalai, Ulrich Wagner, Kathrin Oehl, Karim Saba, Arati Pati, Julio Saez-Rodriguez, Angshumoy Roy, Donald W. Parsons, Peter J. Wild, María Rodríguez Martínez, Pavel Sumazin. 2017-01-27. Inferring clonal composition from multiple tumor biopsies. https://arxiv.org/abs/1701.07940

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