Non-equilibrium odds for the emergence of life

Abstract

Large and complex molecules are building blocks for life. We compute probabilities for their formation from an average non-equilibrium model. As the distance from thermodynamic equilibrium is increased in this model, so too are the chances for forming molecules that would be prohibitively rare in thermodynamic equilibrium. This effect is explored in two settings: the synthesis of heavy amino acids, and their polymerization into peptides. In the extreme non-equilibrium limit, concentrations of the heaviest amino acids can be boosted by a factor of 10,000. Concentrations of the longest peptide chains can be increased by hundreds of orders of magnitude. Since all details of the non-equilibrium driving are averaged out, these findings indicate that, independent of the details of the driving, the mere fact that pre-biotic environments were not in thermodynamic equilibrium may help cross the barriers to the formation of life.