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arXiv · 1705.02539

Impact of a non-uniform charge distribution on virus assembly

Siyu Li·Gonca Erdemci-Tandogan·Jef Wagner·Paul van der Schoot·Roya Zandi
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Abstract

Many spherical viruses encapsulate their genome in protein shells with icosahedral symmetry. This process is spontaneous and driven by electrostatic interactions between positive domains on the virus coat proteins and the negative genome. We model the effect of the icosahedral charge distribution from the protein shell instead of uniform using a mean-field theory. We find that the non-uniform charge distribution strongly affects the optimal genome length, and that it can explain the experimentally observed phenomenon of overcharging of virus and virus-like particles.

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Siyu Li, Gonca Erdemci-Tandogan, Jef Wagner, Paul van der Schoot, Roya Zandi. 2017-05-07. Impact of a non-uniform charge distribution on virus assembly. https://doi.org/10.1103/physreve.96.022401

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