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arXiv · 1706.00976

Effects of electrical and optogenetic deep brain stimulation on synchronized oscillatory activity in Parkinsonian basal ganglia

Shivakeshavan Ratnadurai-Giridharan·Chung Cheung·Leonid Rubchinsky
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Abstract

Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic stimulation is an effective experimental stimulation technique to affect pathological network dynamics. We compared the effects of electrical and optogenetic stimulation of the basal ganglia on the pathological parkinsonian rhythmic neural activity. We studied the network response to electrical stimulation and excitatory and inhibitory optogenetic stimulations. Different stimulations exhibit different interactions with pathological activity in the network. We studied these interactions for different network and stimulation parameter values. Optogenetic stimulation was found to be more efficient than electrical stimulation in suppressing pathological rhythmicity. Our findings indicate that optogenetic control of neural synchrony may be more efficacious than electrical control because of the different ways of how stimulations interact with network dynamics.

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Shivakeshavan Ratnadurai-Giridharan, Chung Cheung, Leonid Rubchinsky. 2017-06-03. Effects of electrical and optogenetic deep brain stimulation on synchronized oscillatory activity in Parkinsonian basal ganglia. https://doi.org/10.1109/tnsre.2017.2712418

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