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arXiv · 1706.03337

Effect of Grafting on Aggregation of Intrinsically Disordered Proteins

Dino Osmanovic·Yitzhak Rabin
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Abstract

A significant part of the proteome is composed of intrinsically-disordered proteins (IDPs). These proteins do not fold into a well-defined structure and behave like ordinary polymers. In this work we consider IDPs which have the tendency to aggregate, model them as heteropolymers that contain a small number of associating monomers and use computer simulations in order to compare the aggregation of such IDPs that are grafted to a surface or free in solution. We then discuss how such grafting may affect the analysis of in-vitro experiments and could also be used to suppress harmful aggregation.

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Dino Osmanovic, Yitzhak Rabin. 2017-06-11. Effect of Grafting on Aggregation of Intrinsically Disordered Proteins. https://doi.org/10.1016/j.bpj.2017.08.062

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