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arXiv · 1711.01553

Hyperpolarization of Amino Acid Derivatives in Water for Biological Applications

S. Glöggler·S. Wagner·Louis-S. Bouchard
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Abstract

We report on the successful synthesis and hyperpolarization of N unprotected α amino acid ethyl acrylate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4$\pm$1% $^{13}$C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.

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S. Glöggler, S. Wagner, Louis-S. Bouchard. 2017-11-05. Hyperpolarization of Amino Acid Derivatives in Water for Biological Applications. https://arxiv.org/abs/1711.01553

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