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arXiv · 1712.06756

Gene regulatory and signalling networks exhibit distinct topological distributions of motifs

Gustavo Rodrigues Ferreira·Helder Imoto Nakaya·Luciano da Fontoura Costa
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Abstract

The biological processes of cellular decision making and differentiation involve a plethora of signalling pathways and gene regulatory circuits. These networks, in their turn, exhibit a multitude of motifs playing crucial parts in regulating network activity. Here, we compare the topological placement of motifs in gene regulatory and signalling networks and find that it suggests different evolutionary strategies in motif distribution for distinct cellular subnetworks.

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Gustavo Rodrigues Ferreira, Helder Imoto Nakaya, Luciano da Fontoura Costa. 2018-04-12. Gene regulatory and signalling networks exhibit distinct topological distributions of motifs. https://doi.org/10.1103/physreve.97.042417

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