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arXiv · 1802.07488

From jamming to collective cell migration through a boundary induced transition

Oleksandr Chepizhko·Maria Chiara Lionetti·Chiara Malinverno·Giorgio Scita·Stefano Zapperi·Caterina A. M. La Porta
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Abstract

Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from a flowing to jammed state as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignement strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

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Oleksandr Chepizhko, Maria Chiara Lionetti, Chiara Malinverno, Giorgio Scita, Stefano Zapperi, Caterina A. M. La Porta. 2018-02-21. From jamming to collective cell migration through a boundary induced transition. https://arxiv.org/abs/1802.07488

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