Mathematics for cryo-electron microscopy

Amit Singer

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arXiv · 1803.06714

Mathematics for cryo-electron microscopy

Amit Singer

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Abstract

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution". This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.

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Amit Singer. 2018-03-12. Mathematics for cryo-electron microscopy. https://arxiv.org/abs/1803.06714

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