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arXiv · 1803.10653

QuipuNet: convolutional neural network for single-molecule nanopore sensing

Karolis Misiunas·Niklas Ermann·Ulrich F. Keyser
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Abstract

Nanopore sensing is a versatile technique for the analysis of molecules on the single-molecule level. However, extracting information from data with established algorithms usually requires time-consuming checks by an experienced researcher due to inherent variability of solid-state nanopores. Here, we develop a convolutional neural network (CNN) for the fully automated extraction of information from the time-series signals obtained by nanopore sensors. In our demonstration, we use a previously published dataset on multiplexed single-molecule protein sensing. The neural network learns to classify translocation events with greater accuracy than previously possible, while also increasing the number of analysable events by a factor of five. Our results demonstrate that deep learning can achieve significant improvements in single molecule nanopore detection with potential applications in rapid diagnostics.

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Karolis Misiunas, Niklas Ermann, Ulrich F. Keyser. 2018-03-27. QuipuNet: convolutional neural network for single-molecule nanopore sensing. https://doi.org/10.1021/acs.nanolett.8b01709

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