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arXiv · 1803.11386

Fodis: software for protein unfolding analysis

Nicola Galvanetto·Andrea Perissinotto·Andrea Pedroni·Vincent Torre
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Abstract

The folding dynamics of proteins at the single molecule level has been studied with single-molecule force spectroscopy (SMFS) experiments for twenty years, but a common standardized method for the analysis of the collected data and for the sharing among the scientific community members is still not available. We have developed a new open source tool, Fodis, for the analysis of the Force-distance curves obtained in SMFS experiments, providing an almost automatic processing, analysis and classification of the obtained data. Our method provides also a classification of the possible unfolding pathways and structural heterogeneity, present during the unfolding of proteins.

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Nicola Galvanetto, Andrea Perissinotto, Andrea Pedroni, Vincent Torre. 2018-03-30. Fodis: software for protein unfolding analysis. https://doi.org/10.1016/j.bpj.2018.02.004

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