Spatial Embedding Imposes Constraints on the Network Architectures of Neural Systems

Abstract

A fundamental understanding of the network architecture of the brain is necessary for the further development of theories explicating circuit function. Perhaps as a derivative of its initial application to abstract informational systems, network science provides many methods and summary statistics that address the network's topological characteristics with little or no thought to its physical instantiation. Recent progress has capitalized on quantitative tools from network science to parsimoniously describe and predict neural activity and connectivity across multiple spatial and temporal scales. Yet, for embedded systems, physical laws can directly constrain processes of network growth, development, and function, and an appreciation of those physical laws is therefore critical to an understanding of the system. Recent evidence demonstrates that the constraints imposed by the physical shape of the brain, and by the mechanical forces at play in its development, have marked effects on the observed network topology and function. Here, we review the rules imposed by space on the development of neural networks and show that these rules give rise to a specific set of complex topologies. We present evidence that these fundamental wiring rules affect the repertoire of neural dynamics that can emerge from the system, and thereby inform our understanding of network dysfunction in disease. We also discuss several computational tools, mathematical models, and algorithms that have proven useful in delineating the effects of spatial embedding on a given networked system and are important considerations for addressing future problems in network neuroscience. Finally, we outline several open questions regarding the network architectures that support circuit function, the answers to which will require a thorough and honest appraisal of the role of physical space in brain network anatomy and physiology.