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arXiv · 1807.09400

Extreme value analysis of gut microbial alterations in colorectal cancer

Stephanie Danni Song·Patricio Jeraldo·Jun Chen·Nicholas Chia
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Abstract

Gut microbes play a key role in colorectal carcinogenesis, yet reaching a consensus on microbial signatures remains a challenge. This is in part due to a reliance on mean value estimates. We present an extreme value analysis for overcoming these limitations. By characterizing a power law fit to the relative abundances of microbes, we capture the same microbial signatures as more complex meta-analyses. Importantly, we show that our method is robust to the variations inherent in microbial community profiling and point to future directions for developing sensitive, reliable analytical methods.

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Stephanie Danni Song, Patricio Jeraldo, Jun Chen, Nicholas Chia. 2018-07-25. Extreme value analysis of gut microbial alterations in colorectal cancer. https://doi.org/10.1103/physreve.99.032413

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