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arXiv · 1809.10458

Protein token: a dynamic unit in protein interactions

Si-Wei Luo·Yi-Hua Jiang·Zhi Liang·Jia-Rui Wu
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Abstract

In this study, we introduced a new unit, named "protein token", as a dynamic protein structural unit for protein-protein interactions. Unlike the conventional structural units, protein token is not based on the sequential or spatial arrangement of residues, but comprises remote residues involved in cooperative conformational changes during protein interactions. Application of protein token on Ras GTPases revealed various tokens present in the superfamily. Distinct token combinations were found in H-Ras interacting with its various regulators and effectors, directing to a possible clue for the multiplexer property of Ras superfamily. Thus, this protein token theory may provide a new approach to study protein-protein interactions in broad applications.

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Si-Wei Luo, Yi-Hua Jiang, Zhi Liang, Jia-Rui Wu. 2018-09-27. Protein token: a dynamic unit in protein interactions. https://arxiv.org/abs/1809.10458

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