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arXiv · 1810.11435

A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions

Aydar Uatay
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Abstract

The interaction of the actin cytoskeleton with cell-substrate adhesions is necessary for cell migration. While the trajectories of motile cells have a stochastic character, investigations of cell motility mechanisms rarely elaborate on the origins of the observed randomness. Here, guided by a few fundamental attributes of cell motility, we construct a minimal stochastic cell migration model from ground-up. The resulting model couples a deterministic actomyosin contractility mechanism with stochastic cell-substrate adhesion kinetics, and yields a well-defined piecewise deterministic process. Numerical simulations reproduce several experimentally observed results, including anomalous diffusion, tactic migration, and contact guidance. This work provides a basis for the development of cell-cell collision and population migration models.

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Aydar Uatay. 2018-10-26. A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions. https://arxiv.org/abs/1810.11435

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