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arXiv · 1811.08885

Guessing the upper bound free-energy difference between native-like structures

Jorge A. Vila
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Abstract

Use of a combination of statistical thermodynamics and the Gershgorin theorem enable us to guess, in the thermodynamic limit, a plausible value for the upper bound free-energy difference between native-like structures of monomeric globular proteins. Support to our result in light of both the observed free-energy change between the native and denatured states and the microstability free-energy values obtained from the observed micro-unfolding tendency of nine globular proteins, will be here discussed.

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Jorge A. Vila. 2018-11-21. Guessing the upper bound free-energy difference between native-like structures. https://doi.org/10.1016/j.physa.2019.122053

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