Nonlinear demixed component analysis for neural population data as a low-rank kernel regression problem

Kenneth W. Latimer

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arXiv · 1812.08238

Nonlinear demixed component analysis for neural population data as a low-rank kernel regression problem

Kenneth W. Latimer

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Abstract

Many studies of neural activity in behaving animals aim to discover interpretable low-dimensional structure in large-scale neural population recordings. One approach to this problem is demixed principal component analysis (dPCA), a supervised linear dimensionality reduction technique to find components that depend on particular experimental parameters. Here, I introduce kernel dPCA (kdPCA) as a nonlinear extension of dPCA by applying kernel least-squares regression to the demixing problem. I consider simulated examples of neural populations with low-dimensional activity to compare the components recovered from dPCA and kdPCA. These simulations demonstrate that neurally relevant nonlinearities, such as stimulus-dependent gain and rotation, interfere with linear demixing of neural activity into components that represent to individual experimental parameters. However, kdPCA can still recover interpretable components in these examples. Finally, I demonstrate kdPCA using two examples of neural populations recorded during perceptual decision-making tasks.

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Kenneth W. Latimer. 2018-12-19. Nonlinear demixed component analysis for neural population data as a low-rank kernel regression problem. https://arxiv.org/abs/1812.08238

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