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arXiv · 1903.03376

Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

R. E. Noskov·A. A. Zanishevskaya·A. A. Shuvalov·S. V. German·O. A. Inozemtseva·T. P. Kochergin·E. N. Lazareva·V. V. Tuchin·P. Ginzburg·J. S. Skibina·D. A. Gorin
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Abstract

Optical fibers are widely used in bioimaging systems as flexible endoscopes capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique which allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), paving the way for combing MRI and optical bioimaging. Our approach is based on Layer-by-Layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI that opens novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.

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R. E. Noskov, A. A. Zanishevskaya, A. A. Shuvalov, S. V. German, O. A. Inozemtseva, T. P. Kochergin, E. N. Lazareva, V. V. Tuchin, P. Ginzburg, J. S. Skibina, D. A. Gorin. 2019-03-08. Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating. https://doi.org/10.1364/oe.27.009868

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