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arXiv · 1903.09386

Forest structure in epigenetic landscapes

Yuriria Cortes-Poza·J. Rogelio Perez-Buendia
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Abstract

Morphogenesis is the biological process that causes the emergence and changes of patterns (tissues and organs) in living organisms. It is a robust, self-organising mechanism, governed by Genetic Regulatory Networks (GRN), that hasn't been thoroughly understood. In this work we propose Epigenetic Forests as a tool to study morphogenesis and to extract valuable information from GRN. Our method unfolds the richness and structure within the GRN. As a case study, we analyze the GRN during cell fate determination during the early stages of development of the flower Arabidopsis thaliana and its spatial dynamics. By using a genetic algorithm we optimize cell differentiation in our model and correctly recover the architecture of the flower.

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Yuriria Cortes-Poza, J. Rogelio Perez-Buendia. 2019-03-22. Forest structure in epigenetic landscapes. https://doi.org/10.1016/j.compbiolchem.2022.107667

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