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arXiv · 1904.03064

Translational control of gene expression via interacting feedback loops

Liang Wang·M. Carmen Romano·Fordyce A. Davidson
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Abstract

Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multi-component mathematical framework for translation we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step-change and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.

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Liang Wang, M. Carmen Romano, Fordyce A. Davidson. 2019-04-05. Translational control of gene expression via interacting feedback loops. https://doi.org/10.1103/physreve.100.050402

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