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arXiv · 1904.11929

Accurate and Robust Alignment of Variable-stained Histologic Images Using a General-purpose Greedy Diffeomorphic Registration Tool

Ludovic Venet·Sarthak Pati·Paul Yushkevich·Spyridon Bakas
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Abstract

Variously stained histology slices are routinely used by pathologists to assess extracted tissue samples from various anatomical sites and determine the presence or extent of a disease. Evaluation of sequential slides is expected to enable a better understanding of the spatial arrangement and growth patterns of cells and vessels. In this paper we present a practical two-step approach based on diffeomorphic registration to align digitized sequential histopathology stained slides to each other, starting with an initial affine step followed by the estimation of a detailed deformation field.

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Ludovic Venet, Sarthak Pati, Paul Yushkevich, Spyridon Bakas. 2019-04-26. Accurate and Robust Alignment of Variable-stained Histologic Images Using a General-purpose Greedy Diffeomorphic Registration Tool. https://arxiv.org/abs/1904.11929

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