Detection of Thalassaemia Carriers by Automated Feature Extraction of Dried Blood Drops

Manikuntala Mukhopadhyay; Manish Ayushmann; Pourush Sood; Rudra Ray; Maitreyee Bhattacharyya; Debasish Sarkar; Sunando Dasgupta

arXiv · 1905.10253

Detection of Thalassaemia Carriers by Automated Feature Extraction of Dried Blood Drops

Manikuntala Mukhopadhyay·Manish Ayushmann·Pourush Sood·Rudra Ray·Maitreyee Bhattacharyya·Debasish Sarkar·Sunando Dasgupta

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Abstract

Thalassaemia, triggered by defects in the globin genes, is one of the most common monogenic diseases. The beta-thalassaemia carrier state is clinically asymptomatic, thus, making it onerous to diagnose. The current gold standard technique is implausible to be used for onsite carrier detection as the method necessitates expensive instruments, skilled manpower and time. In this study, we have tried to classify the carriers from the healthy samples based on their blood droplet drying patterns using image analysis based tools and subsequently develop an in-house program for automated classification of the same. This automatic, rapid, less laborious and cost-effective technique will significantly increase the total number of carriers that are screened for thalassaemia per year in the country, thus, reducing the burden in the state run advanced health facilities.

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Manikuntala Mukhopadhyay, Manish Ayushmann, Pourush Sood, Rudra Ray, Maitreyee Bhattacharyya, Debasish Sarkar, Sunando Dasgupta. 2019-05-24. Detection of Thalassaemia Carriers by Automated Feature Extraction of Dried Blood Drops. https://arxiv.org/abs/1905.10253

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