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arXiv · 1906.02441

Fine-grained simulations of the microenvironment of vascularized tumours

Thierry Fredrich·Heiko Rieger·Roberto Chignola·Edoardo Milotti
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Abstract

One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.

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Thierry Fredrich, Heiko Rieger, Roberto Chignola, Edoardo Milotti. 2019-06-06. Fine-grained simulations of the microenvironment of vascularized tumours. https://arxiv.org/abs/1906.02441

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