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arXiv · 1908.04695

Blinded sample size re-estimation in equivalence testing

Ekkehard Glimm·Lillian Yau·Heike Woehling
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Abstract

This paper investigates type I error violations that occur when blinded sample size reviews are applied in equivalence testing. We give a derivation which explains why such violations are more pronounced in equivalence testing than in the case of superiority testing. In addition, the amount of type I error inflation is quantified by simulation as well as by some theoretical considerations. Non-negligible type I error violations arise when blinded interim re-assessments of sample sizes are performed particularly if sample sizes are small, but within the range of what is practically relevant.

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Ekkehard Glimm, Lillian Yau, Heike Woehling. 2019-08-13. Blinded sample size re-estimation in equivalence testing. https://doi.org/10.1080/19466315.2020.1845232

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