baymedr: An R Package and Web Application for the Calculation of Bayes Factors for Superiority, Equivalence, and Non-Inferiority Designs

Maximilian Linde; Don van Ravenzwaaij

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arXiv · 1910.11616

baymedr: An R Package and Web Application for the Calculation of Bayes Factors for Superiority, Equivalence, and Non-Inferiority Designs

Maximilian Linde·Don van Ravenzwaaij

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Abstract

Clinical trials often seek to determine the superiority, equivalence, or non-inferiority of an experimental condition (e.g., a new drug) compared to a control condition (e.g., a placebo or an already existing drug). The use of frequentist statistical methods to analyze data for these types of designs is ubiquitous even though they have several limitations. Bayesian inference remedies many of these shortcomings and allows for intuitive interpretations. In this article, we outline the frequentist conceptualization of superiority, equivalence, and non-inferiority designs and discuss its disadvantages. Subsequently, we explain how Bayes factors can be used to compare the relative plausibility of competing hypotheses. We present baymedr, an R package and web application, that provides user-friendly tools for the computation of Bayes factors for superiority, equivalence, and non-inferiority designs. Instructions on how to use baymedr are provided and an example illustrates how already existing results can be reanalyzed with baymedr.

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Maximilian Linde, Don van Ravenzwaaij. 2019-10-25. baymedr: An R Package and Web Application for the Calculation of Bayes Factors for Superiority, Equivalence, and Non-Inferiority Designs. https://arxiv.org/abs/1910.11616

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