Cooperatively enhanced reactivity and 'stabilitaxis' of dissociating oligomeric proteins

Jaime Agudo-Canalejo; Pierre Illien; Ramin Golestanian

doi:10.1073/pnas.1919635117

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arXiv · 1911.02350

Cooperatively enhanced reactivity and 'stabilitaxis' of dissociating oligomeric proteins

Jaime Agudo-Canalejo·Pierre Illien·Ramin Golestanian

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Abstract

Many functional units in biology, such as enzymes or molecular motors, are composed of several subunits that can reversibly assemble and disassemble. This includes oligomeric proteins composed of several smaller monomers, as well as protein complexes assembled from a few proteins. By studying the generic spatial transport properties of such proteins, we investigate here whether their ability to reversibly associate and dissociate may confer them a functional advantage with respect to non-dissociating proteins. In uniform environments with position-independent association-dissociation, we find that enhanced diffusion in the monomeric state coupled to reassociation into the functional oligomeric form leads to enhanced reactivity with distant targets. In non-uniform environments with position-dependent association-dissociation, caused e.g. by spatial gradients of an inhibiting chemical, we find that dissociating proteins generically tend to accumulate in regions where they are most stable, a process that we term 'stabilitaxis'.

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Jaime Agudo-Canalejo, Pierre Illien, Ramin Golestanian. 2019-11-06. Cooperatively enhanced reactivity and 'stabilitaxis' of dissociating oligomeric proteins. https://doi.org/10.1073/pnas.1919635117

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