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arXiv · 1911.10239

Squeezed Light Induced Two-photon Absorption Fluorescence of Fluorescein Biomarkers

Tian Li·Fu Li·Charles Altuzarra·Anton Classen·Girish S. Agarwal
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Abstract

Two-photon absorption (TPA) fluorescence of biomarkers has been decisive in advancing the fields of biosensing and deep-tissue in vivo imaging of live specimens. However, due to the extremely small TPA cross section and the quadratic dependence on the input photon flux, extremely high peak-intensity pulsed lasers are imperative, which can result in significant photo- and thermal-damage. Previous works on entangled TPA (ETPA) with spontaneous parametric down-conversion (SPDC) light sources found a linear dependence on the input photon-pair flux, but are limited by low optical powers, along with a very broad spectrum. We report that by using a high-flux squeezed light source for TPA, a fluorescence enhancement of 47 is achieved in fluorescein biomarkers as compared to classical TPA. Moreover, a polynomial behavior of the TPA rate is observed in the DCM laser dye.

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Tian Li, Fu Li, Charles Altuzarra, Anton Classen, Girish S. Agarwal. 2019-11-22. Squeezed Light Induced Two-photon Absorption Fluorescence of Fluorescein Biomarkers. https://doi.org/10.1063/5.0010909

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