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arXiv · 2001.03561

Non-Canonical GC Base Pairs and Mechanochemical Cleavage of DNA

Denis A. Semyonov·Yury D. Nechipurenko
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Abstract

Properties of non-canonical GC Base Pairs and their relation with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the Transient GC Wobble Base Pairs in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms with participation of 5-methylcytosine is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, asymmetric character of these breaks, and an increase in the frequency of breaks in CpG after cytosine methylation.

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Denis A. Semyonov, Yury D. Nechipurenko. 2019-12-30. Non-Canonical GC Base Pairs and Mechanochemical Cleavage of DNA. https://doi.org/10.1002/bies.202000051

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