Thermal induced unfolding refolding of a nucleocapsid COVN protein

Warin Rangubpit; Pornthep Sompornpisut; R. B. Pandey

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arXiv · 2004.00581

Thermal induced unfolding refolding of a nucleocapsid COVN protein

Warin Rangubpit·Pornthep Sompornpisut·R. B. Pandey

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Abstract

Unfolding of a coarse grained COVN protein from its native configuration shows a linear response with increasing temperature followed by a nonmonotonic double peaks in its radius of gyration. The protein conforms to a random coil of folded segments in native state with increasing tenuous and globular structures in specific temperature regimes where the effective dimensions of corresponding structures D is about 1.6 to 2.4. Thermal agitation alone is not sufficient to fully eradicate its segmental folding as few folds are found to persist around such residues as 65W, 110Y, 224L, 374P even at high temperatures.

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Warin Rangubpit, Pornthep Sompornpisut, R. B. Pandey. 2020-04-01. Thermal induced unfolding refolding of a nucleocapsid COVN protein. https://arxiv.org/abs/2004.00581

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