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arXiv · 2005.10746

Tissue failure propagation as mediated by circulatory flow

Gurdip Uppal·Gokhan Bahcecioglu·Pinar Zorlutuna·Dervis Can Vural
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Abstract

Aging is driven by subcellular processes that are relatively well-understood. However the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here we experimentally and theoretically study how cell failure propagates in a synthetic tissue in the presence of advective flow. We argue that cells secrete cooperative factors, thereby forming a network of interdependence governed by diffusion and flow, which fails with a propagating front parallel to advective circulation.

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Gurdip Uppal, Gokhan Bahcecioglu, Pinar Zorlutuna, Dervis Can Vural. 2020-05-21. Tissue failure propagation as mediated by circulatory flow. https://doi.org/10.1016/j.bpj.2020.11.004

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