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arXiv · 2006.10113

From biophysical to integrate-and-fire modelling

Tomas Van Pottelbergh·Guillaume Drion·Rodolphe Sepulchre
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Abstract

This paper proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between Type I and Type II excitability and the transition between spiking and bursting.

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Tomas Van Pottelbergh, Guillaume Drion, Rodolphe Sepulchre. 2020-06-17. From biophysical to integrate-and-fire modelling. https://arxiv.org/abs/2006.10113

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