A coherent likelihood parametrization for doubly robust estimation of a causal effect with missing confounders

Abstract

Missing data and confounding are two problems researchers face in observational studies for comparative effectiveness. Williamson et al. (2012) recently proposed a unified approach to handle both issues concurrently using a multiply-robust (MR) methodology under the assumption that confounders are missing at random. Their approach considers a union of models in which any submodel has a parametric component while the remaining models are unrestricted. We show that while their estimating function is MR in theory, the possibility for multiply robust inference is complicated by the fact that parametric models for different components of the union model are not variation independent and therefore the MR property is unlikely to hold in practice. To address this, we propose an alternative transparent parametrization of the likelihood function, which makes explicit the model dependencies between various nuisance functions needed to evaluate the MR efficient score. The proposed method is genuinely doubly-robust (DR) in that it is consistent and asymptotic normal if one of two sets of modeling assumptions holds. We evaluate the performance and doubly robust property of the DR method via a simulation study.