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arXiv · 2008.07106

Optimal rectification without forward-current suppression by biological molecular motor

Yohei Nakayama·Shoichi Toyabe
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Abstract

We experimentally showed that biological molecular motor F$_1$-ATPase (F$_1$) implements an optimal rectification mechanism. F$_1$ hardly suppresses adenosine triphosphate (ATP) synthesis, which is the F$_1$'s physiological role while inhibiting unfavorable hydrolysis of ATP. This optimal rectification is a high contrast to a simple ratchet model, where the inhibition of the backward current is inevitably accompanied by the suppression of the forward current. The detailed analysis of single-molecule trajectories demonstrated a novel but simple rectification mechanism of F$_1$ with parallel landscapes and asymmetric transition rates.

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Yohei Nakayama, Shoichi Toyabe. 2021-05-21. Optimal rectification without forward-current suppression by biological molecular motor. https://doi.org/10.1103/physrevlett.126.208101

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