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arXiv · 2009.00049

Thermal denaturation of a protein (CoVE) by a coarse-grained Monte Carlo simulation

R. B. Pandey
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Abstract

Thermal response of a protein (CoVE) conformation is studied by a coarse-grained Monte Carlo simulation. Three distinct segments, the N-terminal, Trans-membrane, and C-terminal are verified from its specific contact profile. The radius of gyration (Rg) is found to exhibit a non-monotonic sub-universal thermal response: Rg decays on heating in native phase (low-temperature regime) in contrast to a continuous increase on further raising the temperature before its saturation to a random-coil in denature phase. The globularity index (a measure of effective dimension) of the protein decreases as the protein denatures from a globular to a random-coil conformation.

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R. B. Pandey. 2020-08-31. Thermal denaturation of a protein (CoVE) by a coarse-grained Monte Carlo simulation. https://arxiv.org/abs/2009.00049

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