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arXiv · 2010.15086

Forgery Blind Inspection for Detecting Manipulations of Gel Electrophoresis Images

Hao-Chiang Shao·Ya-Jen Cheng·Meng-Yun Duh·Chia-Wen Lin
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Abstract

Recently, falsified images have been found in papers involved in research misconducts. However, although there have been many image forgery detection methods, none of them was designed for molecular-biological experiment images. In this paper, we proposed a fast blind inquiry method, named FBI$_{GEL}$, for integrity of images obtained from two common sorts of molecular experiments, i.e., western blot (WB) and polymerase chain reaction (PCR). Based on an optimized pseudo-background capable of highlighting local residues, FBI$_{GEL}$ can reveal traceable vestiges suggesting inappropriate local modifications on WB/PCR images. Additionally, because the optimized pseudo-background is derived according to a closed-form solution, FBI$_{GEL}$ is computationally efficient and thus suitable for large scale inquiry tasks for WB/PCR image integrity. We applied FBI$_{GEL}$ on several papers questioned by the public on \textbf{PUBPEER}, and our results show that figures of those papers indeed contain doubtful unnatural patterns.

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Hao-Chiang Shao, Ya-Jen Cheng, Meng-Yun Duh, Chia-Wen Lin. 2020-10-28. Forgery Blind Inspection for Detecting Manipulations of Gel Electrophoresis Images. https://doi.org/10.1109/globalsip.2018.8646594

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