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arXiv · 2011.12694

A framework for modeling cells spreading, motility and the relocation of proteins on advecting lipid membranes

M. Serpelloni·M. Arricca·C. Bonanno·A. Salvadori
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Abstract

The response of cells during spreading and motility is dictated by several multi-physics events, which are triggered by extracellular cues and occur at different time-scales. For this sake, it is not completely appropriate to provide a cell with classical notions of the mechanics of materials, as for "rheology" or "mechanical response". Rather, a cell is an alive system with constituents that show a reproducible response, as for the {\em{contractility}} for single stress fibers or for the mechanical response of a biopolymer actin network, but that reorganize in response to external cues in a non-exactly-predictable and reproducible way. Aware of such complexity, in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility, accounting for the relocation of proteins on advecting lipid membranes.

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M. Serpelloni, M. Arricca, C. Bonanno, A. Salvadori. 2020-11-25. A framework for modeling cells spreading, motility and the relocation of proteins on advecting lipid membranes. https://arxiv.org/abs/2011.12694

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