Glioblastoma Treatments with Photo-Nanotherapeutics Induce Massive Devascularization and Tumor Elimination

Loredana Ricciardi; Sharmistha Chatterjee; Giovanna Palermo; Elisabeta I. Szerb; Alessia Sanna; Francesca Palermo; Nicola Pieroni; Michela Fratini; Roberto Bartolino; Alessia Cedola; Massimo La Deda; Giuseppe Strangi

arXiv · 2101.05152

Glioblastoma Treatments with Photo-Nanotherapeutics Induce Massive Devascularization and Tumor Elimination

Loredana Ricciardi·Sharmistha Chatterjee·Giovanna Palermo·Elisabeta I. Szerb·Alessia Sanna·Francesca Palermo·Nicola Pieroni·Michela Fratini·Roberto Bartolino·Alessia Cedola·Massimo La Deda·Giuseppe Strangi

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Abstract

Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report in vivo studies of GBM treatments based on photo-nanotherapeutics able to induce synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining the photophysical properties of an Ir(III) complex - a new generation PDT agent - with the thermo-plasmonic effects of resonant gold nanospheres. To investigate the damages induced in GBM treated with these nanosystems and exposed to optical radiation, we recurred to the X-ray phase contrast tomography (XPCT). This high-resolution 3D imaging technique highlighted a vast devascularization process by micro-vessels disruption, which is responsible of a tumor elimination without relapse.

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Loredana Ricciardi, Sharmistha Chatterjee, Giovanna Palermo, Elisabeta I. Szerb, Alessia Sanna, Francesca Palermo, Nicola Pieroni, Michela Fratini, Roberto Bartolino, Alessia Cedola, Massimo La Deda, Giuseppe Strangi. 2021-01-13. Glioblastoma Treatments with Photo-Nanotherapeutics Induce Massive Devascularization and Tumor Elimination. https://arxiv.org/abs/2101.05152

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